Dirk M Hermann Selected Research

oxidized low density lipoprotein

1/2019	Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF.
12/2017	Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL.
10/2015	LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118.
6/2015	Thoracic aortic calcification is associated with incident stroke in the general population in addition to established risk factors.
4/2014	Ankle-brachial index predicts stroke in the general population in addition to classical risk factors.
7/2013	LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking.
9/2012	Intima-media thickness predicts stroke risk in the Heinz Nixdorf Recall study in association with vascular risk factors, age and gender.

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Dirk M Hermann Research Topics

Disease

107	Stroke (Strokes) 04/2024 - 11/2002
51	Brain Ischemia (Cerebral Ischemia) 01/2023 - 03/2004
44	Ischemic Stroke 01/2023 - 11/2004
35	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 02/2024 - 01/2005
32	Infarction (Infarctions) 08/2023 - 03/2004
27	Ischemia 12/2022 - 11/2002
27	Brain Injuries (Brain Injury) 01/2022 - 03/2004
14	Inflammation (Inflammations) 01/2024 - 10/2006
13	Brain Edema (Cerebral Edema) 01/2022 - 01/2005
12	Hypoxia (Hypoxemia) 01/2023 - 10/2007
9	Alzheimer Disease (Alzheimer's Disease) 06/2023 - 08/2011
7	Gliosis 01/2023 - 08/2009
5	Neoplasms (Cancer) 01/2024 - 11/2004
5	Neuroinflammatory Diseases 01/2023 - 01/2020
5	Brain Infarction 04/2021 - 10/2015
4	Atrophy 01/2021 - 06/2014
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 11/2006
3	Sepsis (Septicemia) 01/2022 - 01/2020
3	Wounds and Injuries (Trauma) 01/2021 - 10/2012
3	Myocardial Infarction 01/2021 - 01/2013
3	Thrombosis (Thrombus) 01/2021 - 01/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 08/2013
3	Atherosclerosis 12/2019 - 02/2003
3	Chronic Renal Insufficiency 11/2017 - 03/2014
3	Reperfusion Injury 10/2015 - 07/2007
3	Hyperlipidemias (Hyperlipidemia) 10/2015 - 11/2011
3	Edema (Dropsy) 01/2013 - 11/2011
2	Nervous System Diseases (Neurological Disorders) 01/2024 - 02/2008
2	Dementia (Dementias) 01/2024 - 01/2017
2	Cognitive Dysfunction 01/2024 - 03/2014
2	Multiple Sclerosis 01/2022 - 01/2020
2	Hypertension (High Blood Pressure) 01/2021 - 12/2019
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2012
2	Infections 01/2021 - 08/2015

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
13	Oxygen (Dioxygen)IBA 01/2023 - 02/2003
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 01/2005
10	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 06/2006
8	AntioxidantsIBA 01/2022 - 11/2004
8	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021 - 11/2006
8	Caspase 3 (Caspase-3)IBA 01/2019 - 04/2004
8	MelatoninIBA 10/2015 - 03/2002
8	Tissue Plasminogen Activator (Alteplase)FDA Link 11/2012 - 03/2004
7	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 01/2008
7	oxidized low density lipoproteinIBA 01/2019 - 09/2012
7	Erythropoietin FDA Link 01/2011 - 02/2005
6	Biomarkers (Surrogate Marker)IBA 06/2023 - 01/2017
5	MicroRNAs (MicroRNA)IBA 01/2024 - 08/2013
5	CholesterolIBA 01/2024 - 11/2011
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 01/2005
4	CytokinesIBA 02/2024 - 12/2007
4	Amyloid (Amyloid Fibrils)IBA 01/2024 - 01/2016
4	Immunoglobulin G (IgG)IBA 08/2023 - 11/2011
4	AntibodiesIBA 06/2023 - 05/2010
4	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 12/2022 - 01/2019
4	LithiumIBA 01/2022 - 03/2017
4	S44819IBA 02/2020 - 10/2018
4	Adenosine Triphosphate (ATP)IBA 01/2020 - 10/2008
4	Neuroprotective AgentsIBA 01/2020 - 01/2005
4	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2020 - 01/2005
4	Proteasome InhibitorsIBA 11/2016 - 11/2012
4	Apolipoproteins E (ApoE)IBA 10/2015 - 10/2006
4	cresyl violetIBA 05/2010 - 11/2002
3	salicylhydroxamic acid (SHAM)IBA 04/2024 - 10/2006
3	LipidsIBA 01/2024 - 01/2011
3	Amyloid beta-PeptidesIBA 01/2024 - 10/2016
3	Antidepressive Agents (Antidepressants)IBA 12/2022 - 09/2016
3	AcidsIBA 12/2022 - 01/2019
3	LipopolysaccharidesIBA 01/2022 - 01/2020
3	Messenger RNA (mRNA)IBA 01/2022 - 08/2009
3	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 12/2019
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2021 - 02/2005
3	Evans Blue (Blue, Evans)FDA Link 01/2021 - 11/2004
3	Tight Junction ProteinsIBA 12/2020 - 11/2011
3	CeramidesIBA 10/2020 - 01/2019
3	InterferonsIBA 07/2020 - 11/2014
3	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2018 - 06/2012
3	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2017 - 11/2013
3	BSc2118IBA 11/2016 - 11/2012
3	ApolipoproteinsIBA 06/2012 - 10/2006
3	Phosphotransferases (Kinase)IBA 03/2012 - 09/2005
3	indoleIBA 09/2005 - 11/2004
2	Long Noncoding RNAIBA 01/2024 - 01/2022
2	GlycogenIBA 08/2023 - 01/2023
2	Protein Isoforms (Isoforms)IBA 06/2023 - 01/2023
2	1- (2- fluoro- 4- (1H- pyrazol- 1- yl)phenyl)- 5- methoxy- 3- (1- phenyl- 1H- pyrazol- 5- yl)pyridazin- 4(1H)- oneIBA 12/2022 - 01/2022
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 12/2022 - 01/2022
2	AntigensIBA 01/2022 - 01/2021
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2021 - 10/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 12/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 11/2015

Therapy/Procedure

49	Therapeutics 04/2024 - 04/2006
13	Transplantation 11/2021 - 08/2009
3	Injections 11/2016 - 01/2005
3	Lasers (Laser) 10/2015 - 04/2004
3	Axotomy 07/2008 - 02/2005
2	Continuous Positive Airway Pressure 01/2024 - 02/2003
2	Activities of Daily Living (ADL) 01/2023 - 02/2020
2	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2023 - 01/2020
2	Ligation 01/2022 - 01/2022